This paper introduces and assesses the work on Responsible Agricultural Investments by medium scale domestic farmers as they implement aspects of national laws and international guidelines of land-based agricultural investments in Uganda (e.g. VGGTs, RAI and NPL). The medium scale farmers are natives of Uganda with farm sizes ranging from 10 to 35 acres on both private mailo and customary land. A baseline study conducted in 2017 confirmed that often national medium or large-scale agricultural investments are not fully monitored by the Government of Uganda to meet all legal conditions, while international investments are much more expected to comply by both national laws and international guidelines.